(Likewise, if mitochondrial transmission is analyzed, only women need to be considered, since only females transmit their mitochondria to descendants.)Ī model more closely following actual sexual reproduction is the so-called "bisexual Galton–Watson process", where only couples reproduce. This effectively means that reproduction can be modeled as asexual. In the classical family surname Galton–Watson process described above, only men need to be considered, since only males transmit their family name to descendants. Suppose the number of a man's sons to be a random variable distributed on the set For a detailed history see Kendall (19).Īssume, for the sake of the model, that surnames are passed on to all male children by their father. Galton and Watson appear to have derived their process independently of the earlier work by I. Together, they then wrote an 1874 paper titled "On the probability of the extinction of families" in the Journal of the Anthropological Institute of Great Britain and Ireland (now the Journal of the Royal Anthropological Institute). Galton originally posed a mathematical question regarding the distribution of surnames in an idealized population in an 1873 issue of The Educational Times, and the Reverend Henry William Watson replied with a solution. There was concern amongst the Victorians that aristocratic surnames were becoming extinct. The formula is of limited usefulness in understanding actual family name distributions, since in practice family names change for many other reasons, and dying out of name line is only one factor. Likewise, since mitochondria are inherited only on the maternal line, the same mathematical formulation describes transmission of mitochondria. This is an accurate description of Y chromosome transmission in genetics, and the model is thus useful for understanding human Y-chromosome DNA haplogroups. The process models family names as patrilineal (passed from father to son), while offspring are randomly either male or female, and names become extinct if the family name line dies out (holders of the family name die without male descendants). The Galton–Watson process is a branching stochastic process arising from Francis Galton's statistical investigation of the extinction of family names. But the probability of survival of a new type may be quite low even if λ > 1 and the population as a whole is experiencing quite strong exponential increase. For λ ≤ 1, eventual extinction will occur with probability 1. Galton–Watson survival probabilities for different exponential rates of population growth, if the number of children of each parent node can be assumed to follow a Poisson distribution.
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![]() When you do, you will likely be reminded of another well-known burger that you may have tasted before. Sound familiar? Maybe not, but wait until you taste it. It is topped with Tillamook cheddar cheese, caramelized onions, pickles, lettuce, and “Pin Sauce”, served on a potato bun. It starts with two, 2.5 ounce patties that are seasoned with salt, pepper, and olive oil and cooked on a flat top. The Pin Burger is pretty basic, as far as ingredients, but there’s nothing basic about the taste and the sense of familiarity you are likely to feel when you bite into one for the first time. It is the only burger on the menu, and the reason for our visit. The food and drink options on the menu are plentiful, but you know what caught our collective, burger loving eye… the Pin Burger. From SUN 1:00 AM EDT until SUN 11:00 AM EDT, Dade County, Walker County, Catoosa County, Whitfield County, Murray County, Fannin County, Gilmer County, Union County, Towns County, Rabun County, Chattooga County, Gordon County, Pickens County, Dawson County, Lumpkin County, White County, Habersham County, Stephens County, Floyd County, Bartow County, Cherokee County, Forsyth County, Hall County, Banks County, Jackson County, Franklin County, Madison County, Hart County, Elbert County, Polk County, Paulding County, Cobb County, North Fulton County, Gwinnett County, Barrow County, Clarke County, Oconee County, Oglethorpe County, Haralson County, Carroll County, Douglas County, South Fulton County, DeKalb County, Rockdale County, Walton County, Newton County, Morgan County, Greene County, Heard County, Coweta County, Fayette County, Clayton County, Spalding County, Henry County, Butts County, Jasper County, Putnam County, Troup County, Meriwether County, Pike County, Upson County, Lamar County ![]() A data transformation: A boolean-condition can be used to change the state of points. (Since active points do not need to be in one region, we do not use the region of interest term here, but such region can be easy selected). Inactive points are excluded from fitting and all calculations. For calculating the area under the curve we divide the whole area in the form of few rectangular strips of height/length f(x 0 ) and breadth dx and the total area under the curve can be approximately obtained by adding the areas of all the rectangular strips. In Fityk, each point is either active or inactive. This fraction is normalized by multiplying by each dosage form's respective dose. Area under a curve yf(x) can be integrating the function between xa and xb. This is done by comparing the AUC of the non-intravenous dosage form with the AUC for the drug administered intravenously. oral tablet, suppository, subcutaneous, etc.) compared with the bioavailability of the same drug administered intravenously (IV). īioavailability can be measured in terms of "absolute bioavailability" or "relative bioavailability".Ībsolute bioavailability refers to the bioavailability of drug when administered via a non-intravenous (non-IV) dosage form (i.e. ![]() time plots are typically gathered using C-14 labeled drugs and AMS (accelerated mass spectrometry). In order to determine the respective AUCs, the serum concentration vs. This is often measured by quantifying the "AUC". In pharmacokinetics, bioavailability generally refers to the fraction of drug that is absorbed systemically and is thus available to produce a biological effect. The amount eliminated by the body (mass) = clearance (volume/time) * AUC (mass*time/volume). Also, AUC is referenced when talking about elimination. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging) measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug.ĪUC becomes useful for knowing the average concentration over a time interval, AUC/t. darea(y) gives the area under interpolated data points. Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. Fityk is a program for nonlinear fitting of analytical functions. AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure. The AUC (from zero to infinity) represents the total drug exposure across time. ![]() Interpretation and usefulness of AUC values ![]() In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. In the field of pharmacokinetics, the area under the curve ( AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry ). > To unsubscribe from this group and stop receiving emails from it, send an email to To view this discussion on the web visit. > You received this message because you are subscribed to the Google Groups "fityk-users" group. > Could you be more specific? What exactly means that it works not so well? > I have doubts about calculating the area under the curve of my dataset in certain ranges. > On Wed, at 4:54 PM Marcin Wojdyr wrote: The number I obtain from the peak at the right of 550 nm is roughly the same as the peak at the left of 600, (10.3731 and 14.643 respectively), when I was expecting at least three times larger. ![]() If they had done it then I could do it too and the best thing was not to worry about it." Whatever I had to do men had always done. After being severely wounded two weeks before my nineteenth birthday I had a bad time until I figured out that nothing could happen to me that had not happened to all men before me. Then when you are badly wounded the first time you lose that illusion and you know it can happen to you. For his bravery, he received the Silver Medal of Valor from the Italian government-one of the first Americans so honored.Ĭommenting on this experience years later in Men at War, Hemingway wrote: "When you go to war as a boy you have a great illusion of immortality. "Then there was a flash, as when a blast-furnace door is swung open, and a roar that started white and went red," he recalled in a letter home.ĭespite his injuries, Hemingway carried a wounded Italian soldier to safety and was injured again by machine-gun fire. In June 1918, while running a mobile canteen dispensing chocolate and cigarettes for soldiers, he was wounded by Austrian mortar fire. (Ernest Hemingway Photograph Collection, Kennedy Library)ĭuring the First World War, Ernest Hemingway volunteered to serve in Italy as an ambulance driver with the American Red Cross. Hemingway posed for this 1918 portrait in Milan, Italy. The topic of war has also been central to Hemingway forums and conferences organized by the Kennedy Library, including a recent session entitled " Writers on War." And at the Hemingway centennial, held at the library in 1999, many speakers referenced Hemingway's experience in war and his observations on its aftermath as an abiding element of his literary legacy. Scholars, including Seán Hemingway, the author's grandson and editor of the recent anthology, Hemingway on War, continue to use documents and photographs in the Hemingway Collection to educate others about Hemingway and his writings on war. He experienced it firsthand, wrote dispatches from innumerable frontlines, and used war as a backdrop for many of his most memorable works. No American writer is more associated with writing about war in the early 20th century than Ernest Hemingway. Similarly he held his war experience close to his heart and demonstrated throughout his life a keen interest in war and its effects on those who live through it. Hemingway kept the piece of shrapnel, along with a small handful of other "charms" including a ring set with a bullet fragment, in a small leather change purse. ![]() Conversely, had Hemingway not been injured in that attack, he not may have fallen in love with his Red Cross nurse, a romance that served as the genesis of A Farewell to Arms, one of the century's most read war novels. Had the enemy mortar attack been more successful that fateful night, the world may never have known one of the greatest writers of the 20th century. Though not as conspicuous, one object on display is far more consequential: a piece of shrapnel from the battlefield where Hemingway was wounded during World War I. But upon entering, it is hard not to notice the artifacts that ornament the Hemingway Room-including a mounted antelope head from a 1933 safari, an authentic lion-skin rug, and original artwork that Hemingway owned. Kennedy Presidential Library primarily to examine Ernest Hemingway's original manuscripts and his correspondence with family, friends, and fellow writers. Researchers come to the Hemingway archives at the John F. ![]() Discover the real Netherlands in the Dutch Polders & Lake area. ![]()
![]() Despite undergoing several evolutions in BAPE®’s history, the same pattern can be seen on many different garments, from the target version to the snakeskin to the star-decorated Space Camo of 2015 this is the official clothing brand that has made its history in the fashion world with its excellent articles and style statement. Whenever someone thinks of BAPE®, they most likely think of its iconic pattern, that camouflage pattern, also known as “ Cloud Camo,” that has become desired, often showcasing the face of a monkey hidden within its nuances. I want to emphasize that the BAPE® story, I am unable to state, is rich with critical moments, such as collaborations with international brands like Coca-Cola, Comme des Garcons, Adidas, and Supreme, but also with figures of global significance in the field of music and art, such as Kanye West and KAWS, to give two illustrative examples. It is not clear if he thought about who he would be in the 21st Century while watching Planet of the Apes, a film that will give its name to its leading brand, or if he made t-shirts out of pure curiosity for the Japanese musician Cornelius. A Bathing Ape – BAPEĪ BATHING APE® is a leading brand owned by Nigo, a Japanese Fashion Designer. there is a variety of classy outfits sorted for you all in a number of styles, patterns, and designs in this collection. So, if you also want to dress up as you’re favorite celebrities that have a look at this collection of BAPE Pants. Major celebrities like BAPESTA x Kanye West 2007 and KiD CuDi are true fans of this streetwear as they both are seen wearing their outfits. this brand is a famous streetwear clothing spot among some other streetwear brands. bapehoodies is the exclusive online merchandise of NIGO that offers a variety of products. Nigo would go on to design with Fujiwara throughout his career, earning the nickname “Nigo” as result which means Number 2. He used his experience and clout to ensure NOWHERE’s success upon opening. Fujiwara was a prominent figure in the Japanese streetwear scene at that time and, among other things, is credited with being one of the first hip-hop DJs in Japan. The pair also had help from the “Godfather of Harajuku” Hiroshi Fujiwara. Both attended Bunka Fashion Colege which Nigo credits as having done “zero” for him other than giving him that chance to meet Takahashi. That was the year when founder Nigo, real name Tomoaki Nagao, opened a shop in the world-renown fashion district Ura-Harajuku called NOWHERE in partnership with Undercover founder Jun Takahashi. BAPE History of ClothingĪ Bathing Ape has been bathing its ape now since 1993. Explore different sections sorted for you at BAPE Sweater such as hoodies, shirts, and sweatshirts, and find the perfect fit for yourself. And you’ve probably heard YMBAPE yelling about it online or maybe in person if you live in NYC. ![]() ![]() You’ve seen Keith APE wear it to the point you thought he was sponsored. You’ve listened to 21 Savage rap about it. ![]() Yet BAPE Shirts as a streetwear brand is not only popular among fashion lovers but some celebrities are also seen wearing it. Before opening dis brand, he designed custom-made clothes for the famous Justin Bieber specifically for his tour purpose world tour. He created his fashion streetwear brand in about 1993 after his successful work. “And how Jun Takahashi inspired Nigo is really interesting,” he continues. Jian DeLeon, editorial director of streetwear-focused site Highsnobiety, cites “Stüssy, and how the International Tribe directly inspired Hiroshi Fujiwara wif his line Good Enough,” as influences. It’s a bit of a labyrinth, tracing Bape’s lineage. Nigo is a famous Japanese fashion designer Earlier in the decade he came together wif Jun Takahashi to start the label Undercover, and the duo owned the shop Nowhere. A Bathing Ape BAPE Shark Hoodie is the exclusive streetwear clothing brand that was officially founded by Nigo’s real name Tomoaki Nagao. BAPE Hoodie A Bathing Ape Store is the authorized online store that has genuine BAPE clothing items sorted for you. BAPE Shark Hoodie is the best online shopping spot to get some trendy BAPE outfits online. Its success relies on its ownership of so many aspects of daily life, and this ownership would be nigh-on impossible to wrestle from Google or Facebook at this stage. The reality is that WeChat is quite unlikely to gain a serious foothold in the US. As such, that could help to expand WeChat’s reach to Western markets. ![]() Moreover, it has been reported that foreigners based in China have become even more addicted to the app than locals. There are now over 5 million WeChat users based in South Africa alone. This applies to the Chinese government as much as it does to WeChat, and these two strands are interconnected.Īs more and more Chinese workers move to Africa to work on government-funded projects, they tend to take their love of WeChat with them. We should first explore the capabilities that the WeChat app ecosystem provides for an active user base of almost one billion people before we can summarize the experience it offers.Īfrica has been a focus area for expansion, too. However, these comparisons do not tell the full story. It has an app store, so it has similarities with Apple and Google. It contains instant messaging, so it is like WhatsApp. This brings it into direct competition with Weibo in China. WeChat is a major player in the social space, so in that sense it is a bit like Facebook. As a result, defining exactly what the WeChat app is today turns out to be a much more difficult task than it seems. From here, Tencent has added features and opened up the app to outside developers too. The addition of Moments was a particularly important milestone, as it brought with it a news feed featuring updates from friends and contacts. Later rebranded ‘WeChat’ for an international market, the app soon started to encompass more features. ![]() In part, this instant success was down to the ability to make voice calls and leave voice messages, due to the more difficult nature of typing Chinese characters on a smartphone. This project took off quickly, with over 100 million registered users by 2012. Tencent launched an instant messaging app, Weixin, from its Guangzhou Research center in early 2011. First, some background: The history of WeChat WEBUI: Sort WebUI language selection values (Chocobo1).WEBUI: Add meta application name (Daniel Aleksandersen). ![]() WEBUI: Set icon sizes attribute (Daniel Aleksandersen).WEBUI: Add pieces progress bar to General tab (Jesse Smick).WEBUI: Support sorting UI tables via touch (#15205) (Tom Piccirello).WEBUI: Support expanding/collapsing UI folders with arrow keys (Thomas Piccirello).WEBUI: Support navigating UI tables with arrow keys (Thomas Piccirello).WEBUI: Add reverse proxy source IP resolution (#15047) (HiFiPhile).BUGFIX: Apply selected layout to displayed torrent content in "Add New Torrent" dialog (glassez).BUGFIX: Show GUI lock icon after system tray icon is initialized (Chocobo1).BUGFIX: Disable system tray icon menu when app is exiting (Chocobo1).BUGFIX: Disable "add peers" menu items instead of hiding it (Chocobo1).BUGFIX: Use proper string for Korean language (OctopusET).BUGFIX: Apply file priority changes correctly (a-sum-duma, Chocobo1).BUGFIX: Allow deselecting radio buttons in "Torrent options" for mixed torrents (thalieht).BUGFIX: Move a few torrent context menu actions into "Torrent options" dialog (thalieht).BUGFIX: Fix startup with different profiles (jagannatharjun).BUGFIX: Elide text from the right for all columns' header (smigii).BUGFIX: Show "last activity" value under all circumstances (Chocobo1).BUGFIX: Capitalize "peer flags" descriptions (Chocobo1).BUGFIX: Show priority menu at top level if there is no other in Add New Torrent dialog (FozzeY). ![]()
![]() You may also like: 7 Free apps for streaming using Android or iOS gadget Capstone Teleprompter Changing the transparency of the background.Changing the size and location of the widget on the screen of your phone.It is a unique widget that works on all applications (like Facebook Messenger Chat Heads), which provides a flexible and convenient functionality that will help you to easily make very cool performances during live broadcasts, thereby bringing pleasure to your precious viewers and subscribers. Choosing a font, background and text colors, font size.ĭo you want to make perfect speeches? If yes, Oratory will come to aid. ![]() Importing scripts from Google Drive, One Drive, Box, Dropbox, or Gmail.The main features of PromptSmart Teleprompter: Are you a video maker? Then, you should try PromptSmart Teleprompter! It will suit for video producers, podcasters as well as for teachers and business professionals. A lot of users appreciate the app because of unparalleled and intuitive control over your scripts. It automatically follows your voice as you speak. PromptSmart Teleprompter is a smart tool with a VoiceTrack function. Teleprompter Pro Lite is a great helper for presentations, lectures, broadcasters, filmmakers, musicians & singers, business professionals, or any public speaking! However, this function is available in the Paid version only. You can add an unlimited number of scripts. It has all the same features as other professional teleprompters: importing scripts, mirrors, and full-screen modes, changing font size and brightness, adjusting background color, changing the scroll speed. Teleprompter Pro Lite is a simple teleprompter which can be used on your Android or iOS device. creating an unlimited number of scripts.customize the visibility of changing foreground and background colors.landscape and mirrored modes for scrolling scrips.Parrot Teleprompter is a simple tool that will turn your device in a professional teleprompter. Please note – in the settings there is a function of the number of words for a minute, the quality of the video. After recording, the video can be saved, exported to YouTube, shared by reference. You see the text at the top of the record, of course, this text will not appear on the ready video. Click the checkmark – it’s ready! After a few seconds, you can start recording. Next – press on the button “Script” – this is the canvas – and create your own script, all the text, including the title. With it, you can easily recall the needed text, names, surnames, important nuances and so on.Īfter downloading, you need to register or enter a profile on Facebook, Google+. If you are going to record a video for a site, TV, social networks using a mobile device – smartphone or tablet, be sure to install the free BIGVU teleprompter application (iPhone or Android) – a prompter-assistant in real time. You can also check: 1 5 Best Voice Changer Apps for Android & iOS BIGVU – Teleprompter If you want to eat delicious chips you buy Pringles because they are the best in your market, but if you want to easily shoot the amazing video from the first time, then download the Selvi Teleprompter application from the App Store or Play Market and see that it is the best on the market. With this application, you do not need to spend energy on writing cheat sheets, studying text, or editing duplicate videos. In the process of filming a video where it is necessary to speak not some ridiculous spontaneous things, but a clever coherent text, for example, to sing a song beautifully, to make a competent description of the goods or places where you are or elementary – to congratulate someone with a birthday, the problem with the memorization of the desired text arise. Selvi has a function similar to text prompter, which is used on television. Selvi is designed to save your time and effort when shooting a video, and most importantly it’s that the application helps you to look impressive on the video with your participation. It is available in the Play Market and App Store under the name of Selvi Teleprompter. A development team called John Galt Studio released a mobile application available for Android and iOS. ![]() Made In The Maritimes has 2 locations for you to get your locally made gifts! They are located in the Hydrostone market as well as in Bayers Lake. Browse their website, add to your cart and have local products delivered right to your door! There are so many unique gift options and the best part is it’s 100% made in Atlantic Canada! Find pottery, jewelry, books, jams/jellies and so much more!ĭon’t feel comfortable physically visiting stores just yet? Jennifer’s has included online shopping, curbside pickup and local delivery for this year. Jennifer’s of Nova Scotia is another spot that I love to visit during the holidays.
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